Full history for every metric is available with a Kvantra account
Key financial summary
Financials in USD| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | TTM | 2026E | ||
|---|---|---|---|---|---|---|---|---|---|
| Total revenue | $bn | 6.2 | 7.6 | 8.9 | 9.9 | 11.0 | 12.1 | 13.0 | 13.3 |
| Operating profit | $bn | 4.76 | 4.40 | ||||||
| Net profit | $bn | 2.71 | 2.34 | 3.32 | 3.62 | -0.54 | 3.95 | 3.98 | 4.62 |
| EPS reported | $ | 15.32 | 15.54 | ||||||
| Operating cashflow per share | $ | 14.20 | 14.57 | ||||||
| Capex per share | $ | 1.71 | 1.94 | ||||||
| FCF per share | $ | 12.49 | 12.63 | ||||||
| Free cash flow | $bn | 3.19 | 3.20 | ||||||
| Net debt | $bn | -4.68 | -1.81 | ||||||
| Book value equity | $bn | 18.7 | 20.9 | ||||||
| Book value per share | $ | 72.35 | 81.93 | ||||||
| Number of shares | m | 258 | 255.2 | ||||||
| DPS (TTM paid) | $ | 0.00 | 0.00 |
Financial summary
Financials in USD| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | TTM | 2026E | ||
|---|---|---|---|---|---|---|---|---|---|
| Value | |||||||||
| P/E TTM | x | 29.59 | 35.20 | ||||||
| P/B LTM | x | 6.21 | 6.63 | ||||||
| P/S LTM | x | 9.60 | 10.68 | ||||||
| P/FCF LTM | x | 36.30 | 43.31 | ||||||
| EV/EBITDA LTM | x | 23.19 | 27.56 | ||||||
| EV/Sales LTM | x | 9.35 | 10.54 | ||||||
| Earnings Yield LTM | % | 3.38% | 2.84% | ||||||
| FCF Yield | % | 2.76% | 2.31% | ||||||
| Quality | |||||||||
| ROE | % | 21.18% | 20.08% | ||||||
| ROIC | % | 18.54% | 12.79% | ||||||
| Operating margin | % | 39.43% | 33.87% | ||||||
| Gross margin | % | 85.03% | 85.57% | ||||||
| FCF/Sales | % | 26.45% | 24.65% | ||||||
| Growth and momentum | |||||||||
| EPS Growth YoY | % | - | +9.59% | ||||||
| Sales Growth YoY | % | +9.57% | +10.79% | ||||||
| Net Income Growth YoY | % | - | +8.18% | ||||||
| FCF Growth | % | - | -4.04% | ||||||
| Operating Profit Growth | % | - | +10.15% | ||||||
| Dividend and capital structure | |||||||||
| Dividend Yield | % | 0.00% | 0.00% | ||||||
| Dividend Growth | % | 0.00% | 0.00% | ||||||
| Payout Ratio | % | 0.00% | 0.00% | ||||||
| FCF/Debt | x | 0.82 | 0.49 | ||||||
| Net Debt/EBITDA | x | -0.63 | 0.30 | ||||||
| EBIT/Net interest | x | 357.95 | 111.93 | ||||||
| Net debt/market cap | % | -4.04% | -1.30% | ||||||
| Net debt/Equity | x | -0.25 | -0.09 | ||||||
| Gross debt/equity | x | 0.21 | 0.31 | ||||||
ETFs that hold Vertex Pharmaceuticals
| Fund | Ticker | Position# | Weight |
|---|---|---|---|
| iShares MSCI USA Min Vol Factor ETF | USMV | 10 | 1.44% |
| iShares Biotechnology ETF | IBB | 3 | 7.84% |
| First Trust Capital Strength ETF | FTCS | 6 | 2.11% |
| Capital Group Core Balanced ETF | CGBL | 10 | 1.27% |
| Harvest Healthcare Leaders Income ETF | HHL.TO | 7 | 4.94% |
| iShares Nasdaq US Biotechnology UCITS ETF | BTEC.L | 3 | 7.98% |
| Natixis Loomis Sayles Focused Growth ETF | LSGR | 8 | 5.13% |
| Invesco NASDAQ Biotech UCITS ETF | SBIO.L | 3 | 8.01% |
| VanEck Biotech ETF | BBH | 3 | 8.30% |
| Invesco Biotechnology & Genome ETF | PBE | 7 | 4.88% |
Funds with Vertex Pharmaceuticals among their ten largest holdings, largest fund first.
Price target estimates
Based on consensus from external analysts. Not Kvantra's opinion.
Ratings
Based on consensus from external analysts. Not Kvantra's opinion.
ESG
| Metric | 2024 | 2025 | 2026 |
|---|---|---|---|
| ESG-score | |||
| Environmental score | |||
| Social score | |||
| Governance score | |||
| Risk rating |
Company overview
Vertex Pharmaceuticals Incorporated is a leading biotechnology firm primarily focused on the discovery, advancement, and marketing of innovative treatments, particularly for cystic fibrosis (CF). The company offers a range of approved medications for CF patients, including SYMDEKO/SYMKEVI, ORKAMBI, and KALYDECO, which target specific mutations within the cystic fibrosis transmembrane conductance regulator gene. Additionally, they provide TRIKAFTA for individuals with CF aged six years and older who possess at least one F508del mutation. Beyond its established CF therapies, Vertex maintains a robust and diverse clinical pipeline. This includes VX-864, currently in Phase 2 for alpha-1 antitrypsin (AAT) deficiency; VX-147, also in Phase 2, addressing APOL1-mediated focal segmental glomerulosclerosis (FSGS) and other serious kidney conditions; VX-880, a potential treatment for Type 1 Diabetes undergoing Phase 1/2 trials; VX-548, a NaV1.8 inhibitor in Phase 2 for various forms of acute, neuropathic, and musculoskeletal pain; and CTX001, which is in Phase 3 development for severe sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT). The company distributes its pharmaceutical products through specialty pharmacies and distributors across the United States, while international sales are facilitated via a network of specialty distributors, retail chains, hospitals, and clinics. Vertex also engages in numerous strategic collaborations with partners such as Affinia Therapeutics, Arbor Biotechnologies, CRISPR Therapeutics, Kymera Therapeutics, Mammoth Biosciences, Moderna, Obsidian Therapeutics, Skyhawk Therapeutics, Ribometrix, Genomics plc, Merck KGaA, and X-Chem. Established in 1989, Vertex Pharmaceuticals is headquartered in Boston, Massachusetts.
Similar companies
For informational purposes only. Kvantra provides data and quantitative analysis, not investment advice. KvantraRank is a mechanical model output. Analyst price targets and ratings are sourced from third parties and are not Kvantra recommendations. Past performance does not guarantee future results; all investments carry risk.
Vertex Pharmaceuticals Incorporated (VRTX)
| Fund | Ticker | Position# | Weight |
|---|---|---|---|
| iShares MSCI USA Min Vol Factor ETF | USMV | 10 | 1.44% |
| iShares Biotechnology ETF | IBB | 3 | 7.84% |
| First Trust Capital Strength ETF | FTCS | 6 | 2.11% |
| Capital Group Core Balanced ETF | CGBL | 10 | 1.27% |
| Harvest Healthcare Leaders Income ETF | HHL.TO | 7 | 4.94% |
| iShares Nasdaq US Biotechnology UCITS ETF | BTEC.L | 3 | 7.98% |
| Natixis Loomis Sayles Focused Growth ETF | LSGR | 8 | 5.13% |
| Invesco NASDAQ Biotech UCITS ETF | SBIO.L | 3 | 8.01% |
| VanEck Biotech ETF | BBH | 3 | 8.30% |
| Invesco Biotechnology & Genome ETF | PBE | 7 | 4.88% |
Funds with Vertex Pharmaceuticals among their ten largest holdings, largest fund first.
Consensus from external analysts. Not Kvantra's opinion.
Based on consensus from external analysts. Not Kvantra's opinion.
Vertex Pharmaceuticals Incorporated is a leading biotechnology firm primarily focused on the discovery, advancement, and marketing of innovative treatments, particularly for cystic fibrosis (CF). The company offers a range of approved medications for CF patients, including SYMDEKO/SYMKEVI, ORKAMBI, and KALYDECO, which target specific mutations within the cystic fibrosis transmembrane conductance regulator gene. Additionally, they provide TRIKAFTA for individuals with CF aged six years and older who possess at least one F508del mutation. Beyond its established CF therapies, Vertex maintains a robust and diverse clinical pipeline. This includes VX-864, currently in Phase 2 for alpha-1 antitrypsin (AAT) deficiency; VX-147, also in Phase 2, addressing APOL1-mediated focal segmental glomerulosclerosis (FSGS) and other serious kidney conditions; VX-880, a potential treatment for Type 1 Diabetes undergoing Phase 1/2 trials; VX-548, a NaV1.8 inhibitor in Phase 2 for various forms of acute, neuropathic, and musculoskeletal pain; and CTX001, which is in Phase 3 development for severe sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT). The company distributes its pharmaceutical products through specialty pharmacies and distributors across the United States, while international sales are facilitated via a network of specialty distributors, retail chains, hospitals, and clinics. Vertex also engages in numerous strategic collaborations with partners such as Affinia Therapeutics, Arbor Biotechnologies, CRISPR Therapeutics, Kymera Therapeutics, Mammoth Biosciences, Moderna, Obsidian Therapeutics, Skyhawk Therapeutics, Ribometrix, Genomics plc, Merck KGaA, and X-Chem. Established in 1989, Vertex Pharmaceuticals is headquartered in Boston, Massachusetts.
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